Lipids in Health and Disease volume 19 , Article number: 20 Cite this article. Metrics details. Type 2 diabetes mellitus T2DM is closely associated with hyperglycemia, abnormal lipid profiles, chronic low-grade inflammation and gut dysbiosis.

Dietary intervention plays a crucial role in the control of diabetes. Flaxseed oil FO , a plant-derived omega-3 ω-3 polyunsaturated fatty acids PUFAs , is rich in α-linolenic acid ALA which has been proved to benefit for chronic metabolic disease.

However, the exact effects of dietary FO on T2DM remains largely unclear. A diabetic rat model was generated by a single intraperitoneal injection of streptozotocin-nicotinamide STZ-NA. Dietary FO significantly reduced fasting blood glucose FBG , glycated hemoglobin GHb , blood lipid, plasma lipopolysaccharide LPS , interleukin IL -1β, tumor necrosis factor TNF -α, IL-6, ILA and malondialdehyde MDA , compared to control group, respectively.

Acetic acid, propionic acid and butyric acid belonging to short chain fatty acids SCFAs as gut microbiota metabolites, were dramatically increased after FO intervention. Correlation analysis revealed that the relative abundance of Firmicutes and Blautia were positively correlated with IL-1β, TNF-α, IL-6, ILA or LPS, respectively.

Additionally, Bacteroidetes and Alistipes were negatively correlated with LPS. Taken together, dietary FO ameliorated T2DM via suppressing inflammation and modulating gut microbiota, which may potentially contribute to dietary control of diabetes. Prevalence of T2DM presents an observably global public health problem.

According to statistical data of the International Diabetes Federation, more than million people suffered from diabetes worldwide in , and this number was expected to hit million by [ 1 ].

Thus, novel strategies for the control of T2DM are urgently needed. Gut microbiota represents a complicated community involving bacteria in the gastrointestinal tract, which usually maintains a mutually relationship with its host. Numerous studies have demonstrated that the pathogenesis of T2DM is closely related with gut microbiota [ 2 , 3 ].

It has been proven that diabetic individuals possess a high quantity of gram-negative bacteria, especially those belonging to the phylum Proteobacteria [ 4 ].

In a rat model of T2DM, the proportion of Firmicutes was increased, while the abundance of Bacteroides was decreased [ 5 ]. Regulation of gut microbiota may improve metabolism in T2DM [ 6 ]. In T2DM, gut microbiota dysbiosis promotes generation of lipopolysaccharide LPS triggering chronic low-degree inflammation by binding to toll-like receptor 4 TLR-4 [ 7 ].

Excessive translocation of gut-derived LPS to the liver via portal circulation can subsequently promote the inflammatory cascade, leading to the release of inflammatory cytokines involving interleukin IL -1β, IL-6, ILA and tumor necrosis factor TNF -α [ 8 ].

In addition to LPS, other metabolites such as short chain fatty acids, SCFAs of gut microbiota have been demonstrated to target multiple pathways in intestine, liver, pancreas and peripheral blood circulation, resulting in the improvement of gut homeostasis, glycemic control, lipids profile, insulin resistance and inflammation [ 9 ].

Patients with diabetes exhibited lower contents of SCFAs and the proportion of SCFAs-producing gut bacterial communities including Bifidobacterium , Bacteroidetes and Lactobacillus [ 10 ]. At present, SCFAs have been recognized as potential mediators involved in intestinal immune function. Incidence of T2DM was positively related to these unhealthy lifestyles, indicating that dietary factors play a crucial role in the onset and progression of T2DM [ 11 ].

One of the most common dietary approaches against T2DM is the increase in the consumption of omega-3 ω-3 polyunsaturated fatty acids PUFAs [ 12 , 13 ]. A survey has suggested that the low incidence of diabetes in Greenland Eskimos may partly due to high consumption of fish oil which is rich in ω-3 PUFAs, especially eicosapentaenoic acid EPA and docosahexaenoic acid DHA [ 14 ].

Flaxseed oil FO , a plant source of ω-3 PUFAs, has shown to benefit to chronic metabolic, such as diabetes [ 15 ]. The advantage of FO over fish oil is that the food sources are less expensive and are free of heavy metal contamination.

In addition, FO has been demonstrated to suppress the production of TNF-α, IL-6 and IL-1β [ 16 , 17 ]. Accumulating studies have shown that FO protects against inflammation [ 8 ] and oxidative stress [ 18 ] in metabolic disease models. However, the relationships among dietary FO, chronic inflammation and gut microbiota in diabetic rats still remains largely unclear.

The present study aimed to assess the effects of dietary FO and mechanisms related to inflammation and gut microbiota in diabetic rats. Our study may contribute to further understanding of the complicated interaction between diet, the gut microbiota and inflammation of T2DM.

All animal experiments were approved by Ethics Committee of the General Hospital of Ningxia Medical University No. During the whole experimental period, animals were fed with a balanced commercial diet and water ad libitum.

All diets for rats feeding were purchased from TROPHIC Animal Feed High-tech Co. T2DM was induced by the intraperitoneal i. Rats in the pair-fed PF group were i. p injected with an equal volume of citrate buffer and normal saline. Hyperglycemia was confirmed according to the levels of fasting blood glucose FBG , which was determined in day 3 and 7 after injection.

Rats with FBG levels above The fatty acid composition of dietary fats are shown in Additional file 1 : Table S1. Feeds which were not consumed by animals were discarded daily. During the experimental period, body mass BM and FBG were determined weekly to reflect the alteration of basic indicators.

At the end of the experiment, glycated hemoglobin GHb was measured using the Glycosylated Hemoglobin GHb enzyme linked immunosorbent assay ELISA Kit Wuhan ColorfulGene Biological Technology Co. Plasma insulin concentration INS was analyzed using commercial enzyme-linked immunoassay kit Qiaoyi Biology, Anhui, China.

Total cholesterol TC , triglyceride TG , low density lipoprotein LDL and high density lipoprotein HDL levels in each group were respectively determined using AU automatic biochemical analyzer Olympus, Japan.

Plasma LPS levels of each group were determined using limulus amebocyte lysate kit Xiamen Bioendo Technologky Co. The fecal microbial 16S rRNA high throughput sequencing and analysis were performed according to previous studies [ 3 ].

After treatment, 5 rats were randomly selected from each group and transferred to fresh sterilized cages. Then, PCR products were purified with GeneJET TM Gel Extraction Kit Thermo Scientific, USA. The library quality was assessed on the Qubit 2. The library was sequenced on an Illumina HiSeq platform by Beijing Nuo He Zhi Yuan Technology Co.

Quantification analysis of fecal SCFAs was performed using an Agilent A gas chromatography coupled with an Agilent C mass spectrometric detector Agilent Technologies, USA equipped with an HP-5MS column 0.

There was no significant difference in initial BM among diverse groups. These results demonstrated that dietary FO can maintain the BM in T2DM.

Effects of dietary flaxseed oil treatment on glucolipid metabolism in diverse groups. a Schematic diagram of the study.

Body mass BM and FBG for each group were determined weekly. b Body mass BM ; c Fasting blood glucose FBG ; d Glycated hemoglobin GHb ; e Insulin INS ; f Homeostasis model assessment of insulin resistance HOMA-IR ; g TG: Triglyceride; h TC: Total cholesterol; i LDL-C: Low density lipoprotein cholesterol; j HDL-C: High density lipoprotein cholesterol.

FBG levels were significantly increased in diabetic rats compared to control rats Fig. To assess the effects of dietary FO on lipid metabolism in rats, the plasma triglyceride TG , total cholesterol TC , low density lipoprotein cholesterol LDL-C and high density lipoprotein cholesterol HDL-C levels were investigated Fig.

The results showed that concentrations of plasma TC Fig. To investigate the effects of dietary FO on oxidative stress in diabetic rats, we examined the levels of serum SOD and MDA Fig. Serum oxidative marker levels in the four groups of rats.

a superoxide dismutase SOD ; b malondialdehyde MDA. Effects of dietary flaxseed oil treatment on plasma lipopolysaccharide LPS levels in T2DM. In attempt to investigate the effects of dietary FO on inflammation in diabetic rats, the levels of inflammatory cytokines including TNF-α, IL-1β, IL-6, ILA and IL were measured, respectively Fig.

Our results showed that the levels of IL-1β Fig. There results indicated that dietary FO treatment ameliorated the level of inflammation in rats with T2DM. Plasma of rats from diverse groups were collected respectively for detection of IL-1β a , TNF-α b , IL-6 c and ILA d and IL e concentrations using ELISA kit.

We analyzed the correlations among LPS and a series of inflammatory cytokines. LPS was positively correlated with IL-1β, TNF-α, IL-6 and ILA Additional file 3 : Figure S2.

Accumulating studies have been addressing the close linkage between the changes to gut microbiota structure and T2DM [ 3 , 5 , 22 ]. To assess whether FO administration was associated with modulation of gut microbiota composition in diabetic rats, the fecal samples were analyzed by 16S rRNA high throughput sequencing.

Alpha-diversity was used to analyze the abundance and diversity of bacterial community, which was assessed by observed-species index and rarefaction curve.

As shown in Fig. Rarefaction curves which were adopted to evaluate the rationality of the sequencing data Fig. Beta-diversity for analyzing the overall composition of bacterial community was assessed by principal coordinates analysis PCoA Fig.

In addition, NMDS analysis owned similar results Additional file 4 : Figure S3. Alpha-diversity analysis showing difference in terms of abundance and diversity of gut microbiota in diverse groups.

a Observed-species index; b Rarefaction curve. PCoA analysis showing difference in terms of species in fecal samples. Beta diversity was on unweighted UniFrac. Shared OUT analysis of the different groups.

Venn diagram showing the unique and shared OTUs in the different groups. As shown in venn diagram Fig. Taken together, our data revealed that under experimental conditions, FO supplementation had a major effect on Firmicutes and Bacteroidetes.

Relative abundance of microbial species at the phylum level in diverse groups of rat feces. a The relative abundance of microbial species at the phylum level in the feces of rats; b Firmicutes ; c Bacteroidetes ; d the ratio of Bacteroidetes - Firmicutes.

To further understand the composition of gut microbiota in T2DM, we analyzed top 40 taxa of genus level in diverse groups Fig.

Collectively, these results indicated that dietary FO obviously altered the initial proportion of OTUs at genus level, mainly including Blautia and Alistipes. Relative abundance of microbial species at the genus level in the feces. Correlations between a series of inflammatory indicators and the proportions of the above differential bacteria were analyzed at phylum and genus levels, respectively Fig.

These results indicated that gut microbiota and inflammatory indicators interfered and closely correlated. Correlations between inflammatory cytokine and bacterial abundance at the phylum level or genus in the feces of rats. a - e Firmicutes and IL-1β, TNF-α, IL-6, ILA, LPS. f - i Bacteroidetes and TNF-α, ILA, IL-1β, LPS.

j - m Blautia and IL-1β, TNF-α, IL-6, LPS. n - o Alistipes and TNF-α, LPS, respectively. The fecal concentrations of SCFAs mainly including acetic acid, propionic acid and butyric acid, were determined by GC-MS.

These results indicated that FO promotes SCFAs production after increasing the abundance of beneficial bacteria. FO increased the content of SCFAs in fecal intestinal metabolites.

a Sample chromatogram of rats stool. b Acetic acid. c Propionic acid. Correlation analysis between SCFAs and liver inflammatory cytokines. a Acetic acid and IL-1β; b Acetic acid and TNF-α; c Acetic acid and IL-6; d Acetic acid and ILA; e Propionic acid and IL-1β; f Propionic acid and IL-6; g Propionic acid and ILA; h Butyric acid and IL-1β; i Butyric acid and IL-6; j Butyric acid and ILA.

In this study, we investigated the therapeutic effects and associated mechanisms of dietary FO administration on T2DM induced by STZ and NA in rats. Intraperitoneal injection of STZ is mainly attributed to overproduction of reactive oxygen species ROS leading to toxicity of pancreatic cells [ 23 ], which regulate the synthesis and release of insulin via the glucose transporter GLUT and alkylation of DNA.

In contrast, NA prevents excess damage to pancreatic β cells during the induction of T2DM. This T2DM rat model has been widely used to assess the effects and mechanisms of intervention [ 19 , 24 , 25 , 26 ].

Our results demonstrated that supplementary FO showed more effective in alleviation of T2DM, which may be due to the suppression of inflammation and restoration of gut dysbiosis, potentially providing a theoretical foundation as an inexpensive intervention for prevention and treatment of T2DM.

Consumption of ω-3 PUFAs are beneficial for chronic metabolic diseases including T2DM via anti-inflammation and suppressing oxidative stress in clinical and experimental studies [ 12 , 13 ]. FO, as a source of a plant-derived ω-3 PUFAs rich in ALA , has been indicated to show anti-inflammatory properties extensively investigated on the whole body [ 12 , 13 ].

Wang F et al [ 27 ] showed that Perilla oil rich in ALA supplementation improved hypertriglyceridemia and gut dysbiosis in diabetic KKAy mice.

A randomized double-blind placebo-controlled clinical trial revealed that FO supplementation significantly improved levels of gene expression related to insulin, lipid and inflammation in diabetic patients with coronary heart disease [ 28 ].

Yang, Z. Interestingly, we also found that FO treatment effectively alleviated routine parameters including FBG, GHb, liver HE Additional file 5 : Figure S4 and metabolic indicators TC, TG, LDL and HDL , which revealed that FO can regulate the metabolic disorders in consistent with a recent studies [ 8 ].

Oxidative stress is considered to be one of the chief factors responsible for the development and progression of T2DM. Haliga, R et al [ 30 ] showed that dietary flaxseed reduced renal oxidative stress by improving activity of SOD and decreasing thiobarbituric acid reacting substances TBARS in STZ-induced diabetic hamster model.

In this study, dietary FO induced an increase of serum oxidative indicator SOD as well as a decrease of MDA, which was paralleled with previous study [ 31 ]. Collectively, it is indicated that oxidative stress may be linked to the etiology of T2DM and ameliorated by a healthy diet.

LPS derived from pathogenic bacteria, a causal link between gut microbiota and systemic low-grade inflammation, translocates to liver and binds to TLR-4 to induce inflammatory cascade reaction to ultimately lead to diabetes mellitus [ 32 ].

Our data showed that plasma LPS was notably decreased after FO intervention, indirectly demonstrating that integrity and permeability of intestinal mucosa barriers were improved to alleviate peripheral endotoxemia. The damage of intestinal tight junction proteins like Zo-1 and Occludin is essential and critical for LPS translocation.

However, the direct evidence of gut permeability and integrity still needs further research to measure and assess the efforts of the intestinal mucosal barrier, including physical tight junctions Zo-1, Occludin and other components of the gut barriers involving intestinal mucosal immunity γδ T cells, intraepithelial lymphocytes IELs , Tregs, natural killer T NKT cells.

Diabetes present a chronic metabolic disease with a low-grade inflammation [ 33 ]. Studies have demonstrated that activation of neutrophils and macrophage results to oxidative stress as well as inflammatory cytokines release including IL-1β, IL-6 and TNF-α, leading to the decrease of insulin secretion, hepatic steatosis and a series of metabolic disorders in diabetes [ 34 ].

Accelerating studies have demonstrated that ω-3 fatty acids are considered to possess anti-inflammatory ability in chronic metabolic diseases [ 13 ]. In T2DM, inflammation and glucose are interrelated, with reciprocal causation [ 36 ].

High glucose concentration leads to process of protein glycation and the production of advanced glycose end products AGEs. As a consequence, the accumulation of AGEs activates NF-κB to induce TNF-α expression which lead to chronic inflammation [ 37 ]. Intakes of dietary ω-3 fatty acids are associated with reduced lymphocyte proliferation and Th1 cell development [ 38 ], lower circulating levels of leptin, C-reactive protein and other pro-inflammatory cytokines, as well as a lower risk of infection [ 39 ].

Our results showed that a significant augmentation in a series of pro-inflammatory cytokines including IL-1β, TNF-α, IL-6 and ILA in STZ-NA induced diabetic rats. However, the levels of those pro-inflammatory cytokines were dramatically reduced after FO treatment, which was in agreement with a recent study where dietary FO modulated expression of inflammatory genes with alleviation of protein glycation status in STZ-NA induced diabetic rats [ 40 ].

The possible mechanism of anti-inflammation is that ALA in FO diet-mediated GPR activation and β-arrestin 2 recruitment in the inhibition of TLR4 and TNF-α downstream signaling.

But the exact evidence needs to be further researched. IL is an anti-inflammatory cytokine released by Kupffer cells and monocytes. But in present study, we found IL showed no significant difference among diverse groups, which was not paralleled with previous study of T2DM [ 41 ].

We speculated that IL maybe play a complicated role in regulating pro-and anti-inflammation during T2DM. Additionally, regulatory immune cells especially regulatory T lymphocytes Tregs , which may play a critical role in regulation of inflammation to keep maintain immune balance in T2DM.

However, the roles of IL and Treg cells in underlying mechanisms of FO-treated T2DM need to be further investigated. Growing evidences have demonstrated the gut microbiota play a critical role in the development of T2DM [ 3 , 5 , 27 ]. The extraction of flaxseed oil is done from dried flax seeds.

That too, by solvent extraction or by pressing flax seeds. Therefore, flaxseed oil contains only the fat content of flax seeds. While its carbohydrate and protein contents are almost non-existing. For instance, one tablespoon around 15 ml of flaxseed oil offers 0 g of carbs and protein and 14 g of fat.

Alternatively, a similar quantity of whole flax seeds provides 4 g fat, 3 g carbs, and 1. Yet, because of its higher fat content, flaxseed oil provides a greater quantity of ALA as compared to seeds.

Flax seeds and flaxseed oil are outstanding plant sources of omega-3s, chiefly ALA, they give plenty of protein and fiber, so it concludes that Flax seeds are good for diabetic patients. Both forms of flax seeds exert a positive effect on diabetes.

As they are known to improve several of its risk factors. In addition, flax seeds are good for diabetics.

For a diabetic, the maintenance of normal blood sugar levels plays a crucial role. And, fiber is quite important in attaining this. Owing to their high fiber content, flax seeds fall in a low GI food range. Also, it would cause them to elevate gradually, supporting better blood glucose control.

This effect may be due to their soluble fiber content, particularly in mucilage gums. They delay the digestion of food and reduce the absorption of various nutrients such as sugar.

Similarly, in another study, people who had 5 g of flaxseed gum daily with their food had a decrease in fasting blood glucose of 12 than the control group.

Even if flax seeds are good for diabetic patients, studies indicate that similar cannot be true for flaxseed oil. Thus, flax seeds are good for diabetics are just wow.

Flax seeds are rich in omega-3 fat, fiber, and magnesium. There is also an improved insulin sensitivity because of the low glycemic index of flax seeds. Insulin is a hormone responsible for regulating blood sugar. This is known as insulin resistance. Also, it is a risk factor for the occurrence of type 2 diabetes.

Improving it may aid in treating and preventing type 2 diabetes. Flax seeds comprise a good quantity of lignan, which works as a powerful antioxidant. Antioxidants help in improving insulin sensitivity and delaying the progression of diabetes. The lignans present in flax seeds majorly contain SDG or secoisolariciresinol diglucoside.

Studies propose that SDG comes with the potential of improving insulin sensitivity and delaying the progression of both type 1 and 2 diabetes. Instead, ALA from flaxseed oil is also associated with improved insulin sensitivity.

Actually, a study on obese people found a raised insulin sensitivity after they got a daily oral dose of the supplemental form of ALA. Likewise, studies also observed that supplementation with flaxseed oil improved insulin sensitivity greatly. This implies that the higher the dose, the higher will be the improvement in insulin sensitivity, and hence we can say that flaxseeds are good for diabetic patients.

Also Read : Reverse Diabetes Within 30 Days. Diabetes is a risk factor for cardiovascular problems and stroke. Moreover, both flax seeds and flaxseed oil are found to defend these conditions for several reasons. These can be ALA, SDG, and fiber contents.

Soluble fibers such as mucilage gum in flax seeds contain strong cholesterol-reducing activities. This is due to their ability to produce a gel-like compound.

It has an impact on fat metabolism, therefore reducing the absorption of cholesterol. Furthermore, the major lignan of flax seeds, SDG works both as a phytoestrogen and antioxidant. Phytoestrogen is a plant-based compound that imitates estrogen, a hormone.

Antioxidants comprise powerful cholesterol-reducing properties. Also, phytoestrogens play a key role in reducing blood pressure. A study of males with high levels of blood cholesterol established that people who got mg of SDG saw a reduction in LDL bad cholesterol levels than the control group.

In conclusion, omega 3s ALA also contains effective anti-inflammatory properties. Studies recommend that it might aid in curing or even regressing the blocked arteries. These are risk factors for stroke. Besides, research in individuals having hypertension has observed potential results when people had roughly four tablespoons about 30 g of milled flax seeds each day.

They found a decrease of 10 to 15 mm Hg and 7 mm Hg in systolic and diastolic BP top and bottom readings , correspondingly to the control groups. Flax seeds contain rich amounts of soluble fiber, SDG, and ALA. You can also add flaxseed in baked dishes, dairy products, juices, etc.

You can add them to your favourite dishes and as a thickening agent in soups or cooking mixtures. A total of 30 flax seed crackers made using the above ingredients with respective quantities contain the following:.

Eat ground seeds instead of whole flax seeds, as digesting whole flax seeds may not be a good option for people with weak digestion and people of advanced age.

In addition, ground seeds have a higher biological value than whole seeds, making them easier to digest. Flaxseed oil is cold compressed, so do not use it for frying. In addition, it is susceptible to light, so it should be kept in the dark.

However, it is safe to fry food at °F as there is not any reduction in flaxseed oil quality. Reports say 7 grams of flaxseed per day is adequate to offer the desired health benefits, and exceeding it is not recommended.

Flaxseed is full of nutrition containing omega-3, protein and fibres. These help manage the effect of diabetes, blood pressure and other chronic diseases like cancer.

It also stabilises blood sugar levels and cholesterol. You can consume flaxseed and flaxseed oil by adding them to your daily meals and dishes. However, it needs to be consumed in moderation because you may face bloating and other complications if you exceed the limit.

If you are on medication to control your blood sugar levels or high blood pressure, check with your medical practitioner before consuming it not to experience extremely low BP or blood sugar levels. Flaxseed and flaxseed oil may have various health benefits for managing multiple chronic diseases.

For example, it helps lower blood sugar levels and increases insulin sensitivity. Therefore it is suitable for people with diabetes. However, you must consult your physician before including them in your diet. Flaxseed has a dominant nutritional index as compared to oil.

However, both have their benefits. The oil contains more omega-three fatty acids, whereas flax seeds are a rich source of fibres, proteins and carbohydrates. Most research has already proved that flaxseed is beneficial for lowering and controlling blood sugar levels and insulin sensitivity.

Therefore, it is a good option for diabetic patients. However, no one food or medication alone can keep diabetes at bay. USDA provides no limit USDA for flaxseed oil. However, several other studies claim that 1 to 2 tablespoons of flaxseed oil 7gg can consume daily. If you want to lower cholesterol levels and improve digestion, take it in the morning.

Taking flax seed in the morning is more beneficial than taking it at night. It controls your blood sugar levels and lowers cholesterol levels if taken in the morning. If you want to get only omega three from it, you can also have it as a snack at bedtime.

Flaxseed oil does not clog arteries. On the contrary, it even helps unclog arteries and reduces cholesterol levels in the body. Also, it has high fibre content, which controls inflammation and high blood pressure.

One tablespoon of flaxseed oil contains 37 Calories, 2 g of polyunsaturated fat contains omega3 , and 2 g of dietary fibres. Several studies show that flaxseed, flaxseed oil, and other flax seed containing products contain renal protective effects.

Author Dr. Joel Kahn. You Might Also Enjoy In this study including patients with prehypertension, a month Tai Chi intervention was more effective than aerobic exercise in reducing SBP. These findings suggest that Tai Chi may help promote the prevention of cardiovascular disease in populations w.

The effect of an encapsulated formulation Vascanox® HP that combines dietary sources of inorganic NO3- and S-allylcysteine SAC , a source of H2S from garlic, on NO bioavailability is presented. Approximately one in five patients who underwent CABG also had high Lp a.

High Lp a at baseline was associated with increased all-cause mortality and risk for adverse events after surgery. Flaxseed may also aid in cholesterol reduction. A week study of people with hypertension found that eating 4 tablespoons 30 g of flaxseed per day significantly reduced BMI, lipid levels, and blood pressure.

Sustaining blood sugar control is critical for patients with diabetes, and fibre plays an important role. Flax extracts have been reported as a low-glycemic food due to their high fibre content. This means that eating them will not cause your blood glucose levels to spike but would instead induce them to an "on" position, promoting blood sugar control.

Lignans make up a sizable portion of dietary fibre. This summarises your query is flaxseed is good for patients with diabetes. Insulin hormone controls blood sugar levels.

If someone's body has trouble trying to respond to insulin, it will require more of it to lessen your blood glucose levels. This is associated with insulin resistance , a risk factor for developing type 2 diabetes. Diabetes is a cause of cardiovascular disease and stroke, and flax seeds and oil have been shown to better shield against some of these conditions for various reasons, including their fibre, SDG, and ALA content.

Because of the fibre content, the glycemic index of flaxseed is low, which aids in blood sugar control. Researchers discovered that a compound in flaxseed has several benefits in living creatures to type 1 diabetes in the most recent study on 1 diabetes solutions.

Improved glucose utilisation in the liver, normalised glucose trying to form action in the liver as well as muscle tissues, and "limited hepatocellular and intestinal galactosidase inhibition activity that also contributes to lower comment blood sugar elevations" are among the benefits.

Flaxseed had a significant positive impact on glucose control in a study of insulin-resistant patients. especially mucilaginous gums, which also slow nutritional digestion and reduce nutrient absorption. Flaxseed has a glycemic index GI of 35, indicating that it is a low-GI food.

As it has a low GI, flax seeds are known as a low-glycemic food owing to their high fibre content. This means that eating them will not cause one's blood sugar levels to spike but would instead end up causing people to " to rise steadily, trying to promote blood sugar control.

Banana Seed Smoothie is a delicious way to absorb flax seeds for diabetes. This nutrient-dense smoothie will provide you with essential nutrients. Also read about are dates good for diabetes. Purchase some fresh yoghurt. Combine two tablespoons of chia and flax seeds.

Take a bite of your creamy yoghurt with a crunchy twist. To reap the most nutritional benefits from flax seeds, eat them first thing in the morning. You can eat it with your morning tea or mix it into your water. Because flax seeds are high in fibre, they help with digestion and improve digestive system movements in the morning.

Hence, flaxseed and diabetes type 2 can be cured with accurate and regular usage. Similarly, studies in rats with insulin resistance found that supplementing with flaxseed oil improved insulin sensitivity in a dose-dependent manner, meaning that the larger the dose, the greater the improvement 21 , 22 , Diabetes is a risk factor for heart disease and stroke, and both flax seeds and flaxseed oil have been shown to help protect against these conditions for multiple reasons, including their fiber, SDG, and ALA contents 24 , 25 , Soluble fibers like the mucilage gum in flax seeds have cholesterol-lowering properties.

While antioxidants have cholesterol-lowering properties, phytoestrogens play an important role in blood pressure reduction 29 , One week study in 30 men with high blood cholesterol levels determined that those who received mg of SDG experienced a decrease in LDL bad cholesterol levels, compared with the control group Research suggests that it may help treat — and even regress — clogged arteries, which are a risk factor for stroke 32 , They observed a reduction of 10—15 mm Hg and 7 mm Hg in systolic and diastolic blood pressure the top and bottom numbers of the reading , respectively, compared with the control groups 34 , Flax seeds and flaxseed oil are rich in soluble fiber, ALA, and SDG, all of which may reduce heart disease risk and improve blood sugar control and insulin sensitivity.

Though flax seeds and flaxseed oil have multiple health benefits, they may interact with some medications that are used to regulate blood sugar and cholesterol levels This especially applies to flaxseed oil, as it has a higher omega-3 content.

For example, omega-3 fatty acids have blood-thinning properties, which may increase the effect of blood-thinning drugs, such as aspirin and warfarin, which are used to prevent blood clots Also, omega-3 fatty acid supplements may interfere with blood sugar regulation by decreasing blood sugar levels.

This means that they might lower blood sugar too much, necessitating an adjustment to your dosage of blood-sugar-lowering medications. Still, the omega-3 fatty acids in flax seed or flaxseed oil supplements may make some cholesterol-lowering medications more efficient In any case, you should consult your healthcare provider before adding flax seeds or flaxseed oil to your daily routine.

Eating flax seeds or flaxseed oil may interfere with medications used to manage blood sugar and blood cholesterol levels. Thus, you should be cautious before consuming them. Flax seeds and flaxseed oil are very easy to cook with.

They can be consumed whole, milled, and roasted, or as an oil or flour You can also find them in numerous food products, such as baked goods, juices, dairy products, and even beef patties 4 , Also, you can incorporate them into almost everything you cook, including as a thickening agent for soups and sauces or in your favorite coating mixture for a nice crust.

Mix the dry ingredients in a small bowl. Then pour the water over it and use your hands to form a dough. Place the dough between two pieces of parchment paper and roll it to your desired thickness.

Remove the top portion of the parchment paper and cut the dough into squares. This recipe yields about 30 crackers. Place the dough on a baking sheet and bake it at °F °C for 20—25 minutes. Let it cool and then serve them with your favorite dip.

As for flaxseed oil, you can add it to dressings and smoothies, or you can find flaxseed oil capsules in stores and online. Flax seeds and flaxseed oil can be eaten whole, ground, as oil, or in capsules, as well as added to sweet and savory dishes alike. Flax seeds and flaxseed oil have multiple health benefits that may help people with diabetes manage the condition.

However, you should be mindful before consuming them, as they may interact with other medications prescribed for the treatment of diabetes. Finding the right diabetes-friendly diet may help you to lose weight. Learn more about the options.

Flax seeds are small seeds. They are are high in fiber and offer many health benefits. Here is detailed health and nutrition information on flax seeds.