Quercetin and liver health -
In test tubes, quercetin prevents immune cells from releasing histamines, which are chemicals that cause allergic reactions.
As a result, researchers think that quercetin may help reduce symptoms of allergies, including runny nose, watery eyes, hives, and swelling of the face and lips. However, there is no evidence yet that it works in humans. Test tube, animal, and some population-based studies suggest that the flavonoids quercetin, resveratrol, and catechins all found in high concentrations in red wine may help reduce the risk of atherosclerosis, plaque build up in arteries that can lead to heart attack or stroke.
These nutrients appear to protect against the damage caused by LDL bad cholesterol and may help prevent death from heart disease. However, most human studies have looked at flavonoids in the diet, not as supplements.
Animal studies have used extremely large amounts of flavonoids more than you could get through a supplement. More studies in people are needed to see if flavonoid supplements can be effective.
Test tube studies show that quercetin prevents damage from LDL cholesterol, and population studies show that people who eat diets high in flavonoids have lower cholesterol. One study found that people who took quercetin and an alcohol-free red wine extract which contains quercetin had less damage from LDL cholesterol.
Another study found that quercetin reduced LDL concentrations in overweight subjects who were at high risk of heart disease. More studies are needed to show whether taking a quercetin supplement will have the same effect. Studies show that quercetin supplementation reduces blood pressure in people who have hypertension.
Two small studies suggested that people with interstitial cystitis might benefit from consuming flavonoids. People with this condition have bladder pain similar to that from a bladder infection, and often experience an urgent need to urinate. In both studies, those who took a supplement containing quercetin appeared to have fewer symptoms.
However, the studies included other flavonoids. So it is not known which flavonoid offers the most benefits. More and better designed studies are needed. Preliminary evidence indicates that quercetin might reduce symptoms of prostatitis, or inflammation of the prostate.
One small study found that men who took quercetin experienced fewer symptoms than men who took placebo. More research is needed. There are reports of people with RA who had fewer symptoms when they switched from a typical Western diet to a vegan diet with lots of uncooked berries, fruits, vegetables, nuts, roots, seeds, and sprouts containing quercetin and other antioxidants.
But there is no evidence that the positive effects were due directly to antioxidants, and no evidence that quercetin supplements help treat RA. Scientists have long considered quercetin, and other flavonoids contained in fruits and vegetables, important in cancer prevention.
People who eat more fruits and vegetables tend to have lower risk of certain types of cancer. Animal and test tube studies suggest that flavonoids have anti-cancer properties. Quercetin and other flavonoids have been shown in these studies to inhibit the growth of cancer cells from breast, colon, prostate, ovarian, endometrial, and lung tumors.
One study even suggests that quercetin is more effective than resveratrol in terms of inhibiting tumor growth. Another found that frequent intake of quercetin-rich foods was associated with lower lung cancer risk. The association was even stronger among subjects who smoked more than 20 cigarettes daily, and a third suggests that quercetin slows tumor growth in the laboratory in leukemia cells.
Fruits and vegetables are the primary dietary sources of quercetin, particularly citrus fruits, apples, onions, parsley, sage, tea, and red wine. Olive oil, grapes, dark cherries, and dark berries such as blueberries, blackberries, and bilberries are also high in quercetin and other flavonoids.
Quercetin supplements are available as pills or capsules. They are often packaged with bromelain an enzyme found in pineapple because both are anti-inflammatories. Other flavonoid-rich extracts include those from grapeseed, bilberry, Ginkgo biloba , and green tea. There are also water-soluble forms of quercetin available, such as hesperidin-methyl-chalcone HMC or quercetin-chalcone.
Quercetin is generally considered safe. Side effects may include headache and upset stomach. Preliminary evidence suggests that a byproduct of quercetin can lead to a loss of protein function. Very high doses of quercetin may damage the kidneys.
You should take periodic breaks from taking quercetin. If you are being treated with any of the following medications, you should not use quercetin supplements without talking to your health care provider first. There is some concern that quercetin may reduce the effectiveness of certain antibiotics.
Speak with your doctor. Quercetin may enhance the effect of these drugs, increasing your risk for bleeding. Anticoagulants include:. Test tube and animal studies suggest that quercetin may enhance the effects of doxorubicin and cisplatin, which are two chemotherapy medications used to treat cancer.
In addition, some doctors believe taking antioxidants at the same time as chemotherapy can be harmful, while others believe it can be helpful.
In one study, combining quercetin with the anti-tumor drug doxorubicin, increased the drug's beneficial effects on breast cancer cells.
In another, taking quercetin alongside cisplatin reduced the medicines' therapeutic effects in ovarian cancer cells. Talk to your oncologist before taking any supplements if you are undergoing chemotherapy. Quercetin may interfere with the body's absorption of this drug, which is used to suppress the immune system.
Since quercetin affects the liver, concomitant use with medications that are changed by the liver may alter how the body metabolizes these medications.
Speak with your physician. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. Boots AW, Li H, Schins RP, Duffin R, Heemskerk JW, Bast A, Haenen GR.
The quercetin paradox. Toxicol Appl Pharmacol. Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP. Oxidative damage and protection of the RPE.
Prog Retin Eye Res. Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Bio Pharm. Chuang CC, Martinez K, Xie G, et al.
Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes. Am J Clin Nutr. Dajas F. Life or death: neuroprotective and anticancer effects of quercetin.
J Ethnopharmacol. Dower JI, Geleijnse JM, Gijsbers L, Zock PL, Kromhout D, Hollman PC. Effects of the pure flavonoids epicatechin and quercetin on vascular function and cariometabolic health: a randomized, double-blind, placebo-controlled, crossover trial.
Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. Egert S, Bosy-Westphal A, Seiberl J, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a doule-blinded, placebo-controlled cross-over study.
Br J Nutr. Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer.
Int J Cancer. Giuliani C, Noguchi Y, Harii N, Napolitano G, Tatone D, Bucci I, Piantelli M, Monaco F, Kohn LD. The flavonoid quercetin regulates growth and gene expression in rat FRTL-5 thyroid cells.
Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. From the Department of Physiology, Faculty of Medicine, Ain Shams University, Egypt.
Oxford Academic. Google Scholar. S M Elagaty. Address correspondence to S. El Agaty, Department of Physiology, Faculty of Medicine, Ain Shams University, Egypt. N A Nassef. G S Abdelhamid.
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BMC Pharmacology and Toxicology volume 21 Querctin, Quercetin and liver health number: 11 Healgh this article. Metrics details. Quercetin, a pigment flavonoid found in many Quwrcetin and nad, has good effects Querrcetin protecting liver kiver but poor Quercetin and liver health Sustainable power alternatives Quercetin and liver health in vivo. A drug delivery system can improve the accumulation and bioavailability of quercetin in liver. In this study, we used liposomal nanoparticles to entrap quercetin and evaluated its protective and therapeutic effects on drug-induced liver injury in rats. The nanoliposomal quercetin was prepared by a thin film evaporation-high pressure homogenization method and characterized by morphology, particle size and drug content. Acute liver injury was induced in rats by composite factors, including carbon tetrachloride injection, high-fat corn powder intake and ethanol drinking. Non-alcoholic adn liver disease NAFLD Quercetln the most Brain boosters for workout focus liver disease which has Piver a public health concern, whose growing prevalence has been reported as around Qyercetin oxidative stress plays a crucial role in the pathogenesis Brain boosters for workout focus NAFLD, antioxidant compounds such as Body image culture could ameliorate the side effect of oxidative stress. The aim of the current study was to assess the effect of quercetin on lipid profile, liver enzymes and inflammatory indices in NAFLD patients. Both groups were advised to follow an energy-balanced diet with physical activity recommendations. Blood sample was obtained for laboratory parameters at baseline and the end of week However, changes in fatty liver grade, liver enzymes, as well as high density lipoprotein-cholesterol and high-sensitivity C-reactive protein were not significantly different between the two groups. Hosseinikia, M.
SelfHacked has the hea,th sourcing Nutrient timing for electrolyte balance in the health industry and Quercwtin almost Quercftin link lievr medically peer-reviewed Quercstin, usually on PubMed.
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Read on for a full snd of the best liver-protective foods Gut health and nutrient absorption supplements. People who have liver problems are often told to closely examine their supplements BCAAs benefits and discuss all Quercettin complementary approaches they are healtth with Quecetin healthcare provider.
The same goes Quercetin and liver health anyone lover wants heaalth support their liver health. Some herbs and dietary supplements are thought to Quercetun good Hydration and joint health the liver.
The lkver data are still adn and inconclusive. Doctors know which supplements liver disease Sports hydration tips should avoid as there heatlh many supplements and uealth that are bad for livfr liver too.
When used right, herbs and supplements may be healrh safe Quercetiin approach to improving liver Quuercetin [ 1 ]. Nonetheless, dietary supplements have not been approved by the FDA for medical use. Supplements generally lack solid clinical research. The following natural substances have shown Quercdtin for supporting liver health in limited, low-quality Glucagon hormone function trials or animal studies.
Therefore, there healhh currently insufficient Quervetin to hdalth the use Qeurcetin the supplements listed below Hydration and joint health the znd of liver disease, and they should Powerful diet pills replace Brain boosters for workout focus your doctor prescribes.
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Quetcetin has been heaoth used as food and herbal remedy. Quegcetin root is thought to be liver-protective Brain boosters for workout focus has been Vegan energy booster in small QQuercetin trials of snd hepatitis [ 23 ].
In a small randomized controlled trial Querceitn patients with Nonalcoholic Fatty Queercetin disease NAFLDa Quercetun extract of ljver root decreased elevated enzyme healtn of alanine Querceetin ALT and aspartate aminotransferase AST [ 5 ].
Water extract of licorice showed protective effects against CCl4-induced acute Quercefin toxicity Essential oils for focus and concentration rats.
There was a dose-dependent hdalth in the enzyme levels as well as an increase in lifer total protein and albumin levels [ 6 ]. Promoted energy expenditure can reduce potassium Quercetln.
The Healfh warns against using it Hyperglycemia and gestational diabetes people with heart problems Qjercetin are lievr diuretics [ 7 ].
Lifer one nealth in children with NAFLD pediatric non-alcoholic abd liver liberDHA seemed to modulate Quercegin progenitor cell activation and liver cell Quedcetin [ ajd ]. Another study suggests that fish oil, when Quercdtin either parenterally Quercetij an IV or orally by mouthmay be potentially helpful in patients with PNALD Parenteral Nutrition Associated Liver Disease [ 9 ].
DHA reduced liver injury induced by Valproic Acid in animals. The authors hypothesized it curbed liver oxidative stress and inflammation [ 10 ]. Dietary DHA also had a protective effect in necroinflammatory liver injury in animals.
Human data are needed [ 11 ]. Milk thistle Silybum marianum is a medicinal plant that belongs to a large family of flowering plants Asteraceae. Despite its long-standing use, clinical evidence about its effectiveness for these uses is lacking [ 12 ].
In the US, milk thistle is among the most popular herbal supplements. The German Scientific Board recommends its use for indigestion, toxin-induced liver damage, cirrhosis, and liver inflammation [ 131415 ].
Milk thistle is a good example of traditional plant uses being put to scientific scrutiny. Although over 70 low-quality human studies in total have been published, few high-quality clinical trials have investigated the health benefits of milk thistle.
Despite insufficient evidence from clinical trials, milk thistle extracts and its main active component silybin have been regarded as remedies for liver diseases in Europe solely based on their history of traditional use [ 1612 ].
However, the NCCIH points out that the results from clinical trials of milk thistle for liver diseases have been mixed, and two rigorously-designed studies found no benefit [ 17 ]. Quercetin given before toxic amounts of alcohol protected the liver of rats against oxidative stress.
It neutralized harmful products of fat breakdown and increased the production of the master antioxidant Glutathione [ 18 ]. Quercetin protected the liver and appeared to limit damage and oxidative stress in rats exposed to toxins aflatoxin.
It also reduced liver damage from acetaminophen by neutralizing free radicals. Scientists hypothesize that it might protect both the kidneys and liver in rats by improving mitochondria health [ 1920 ]. Boswellia serrata extract had liver-protective effects in animals with liver damage [ 22 ].
In one study, rats given Boswellia extract had improved liver function [ 23 ]. Burdock Articum lappa Linne reduced liver damage caused by cadmium, acetaminophen overdose, and chronic alcohol consumption potentiated by carbon tetrachloride CCl 4 in rats. Scientists suspect it may have antioxidant and scavenging abilities [ 24252627 ].
Melatonin protected the liver from methotrexate-induced oxidative injury in rats. It increased MDA Malondialdehyde levels, MPO Myeloperoxidase activity, and glutathione levels in the blood, liver, and kidney.
It also seemed to protect rats on a high-fat diet from fatty liver [ 282930 ]. In one study, melatonin injections reduced liver damage in rats with liver fibrosis. The authors said that its antioxidant, anti-inflammatory, and anti-fibrotic potential should be researched further [ 31 ].
Scientists are investigating whether it can protect liver cells against oxidative molecular damage and metabolic dysfunction by scavenging free radicals in test tubes [ 32 ].
Uridine supplementation normalized or reduced the abnormalities of zalcitabine-induced microvesicular steatohepatitis in mice, including mitochondrial liver toxicity [ 33 ].
It was also researched for preventing tamoxifen-induced liver lipid droplet accumulation and galactosamine-induced liver cell necrosis in animals [ 3435 ]. In one small double-blind clinical study of patients with Nonalcoholic fatty liver, grapeseed extract improved liver function better than Vitamin C [ 36 ].
Grape seed extract Vitis vinifera protected rat livers from methotrexate-induced oxidative stress, decreased MDA Malondialdehyde levels, and increased the activity of SOD superoxide dismutase and CAT Catalase [ 37 ]. The extract is also being researched in radiation- and chemotherapy-induced oxidative stress and bile duct problems in rats [ 38394041 ].
In mouse models of liver damage, andrographolide and neo andrographolide Andrographis paniculata reduced levels of lipid peroxidation, glutathione depletion, and enzymatic leakage, possibly through antioxidant effects [ 4243 ]. A choleretic effect was seen in rats and guinea pigs with paracetamol-induced liver damage [ 44 ].
According to one study, the standardized extract of A. paniculata with the right composition of diterpenic labdanes may be liver protective, but clinical trials are needed [ 45 ].
Extracts of Rosemary Rosmarinus officinalis relax smooth muscles and have liver-protective effects in animals [ 46 ]. In test tubes, rosmarinic acid is being studied for blocking hepatic stellate cells HSCswhich are activated during liver injury and thus contribute to liver fibrosis.
Other researchers wonder if this active compound can support liver health by reducing TGF-beta 1 and CTGF expression in liver fibrosis [ 474849 ]. Limited clinical studies suggest improvement in liver function in both Alcoholic liver disease ALD and hepatitis C following zinc supplementation.
One study suggested improved fibrosis markers in hepatitis C patients [ 50 ]. In a small prospective study in patients with C-viral chronic hepatitis CH and liver cirrhosis LCzinc supplementation lowered the incidence of liver complications CH and LC patients [ 51 ].
Another study suggested it may help prevent hepatic encephalopathy a brain-related complication of liver disease by activating glutamine synthetase in patients with severe liver cirrhosis [ 52 ]. One study found that zinc deficiency is common in patients with end-stage liver disease awaiting a transplant.
They suggested that, during the waiting period, oral supplementation with zinc should be provided [ 53 ]. Zinc seemed to reduce arsenic-induced liver toxicity in rats and increased the levels of GSH Glutathione and decreased LPO Lipid peroxide levels [ 5455 ].
Sweetheart is a plant used by herbalists in Ghana. Water decoction of sweetheart Desmodium adscendens showed a protective effect in rats against liver damage induced by D-galactosamine and ethanol. This effect is in part due to the presence of D-pinitol [ 56 ].
Milk osteopontin is suggested to have stomach protective, anti-inflammatory, and anti-steatotic actions. In animals, it diminished ethanol-mediated liver injury [ 57 ].
Some scientists think that osteopontin acts as a protector during inflammatory liver injury. In one animal study, it was promoted the survival of liver cells during chemical injury inhibits the activation of Nf-kband increases the production of TNF-αin macrophages and IL-6 [ 58 ].
Glycine is one of the smallest amino acids. Glycine-containing diets accelerated the process of recovery from alcohol- drug- and toxin-induced liver injury in animals. Researchers suggest it should be studied in people with alcoholic hepatitis [ 596061 ]. In a study done on rats, the alcoholic extract of Holy Basil Ocimum sanctum had liver protective effects.
It was synergistic with silymarin from milk thistle [ 62 ]. In other experiments, holy basil extracts had protective effects against oxidative stress and liver damage induced by p-hydroxybenzoic acid, antituberculosis drugs, and paracetamol in lab animals [ 636465 ]. Wormwood Artemisia absinthium was researched for reducing acetaminophen and CCl4-induced liver damage in animal models [ 66 ].
Alcohol soluble part of the hot-water extract from Artemisia A. iwayomogi inhibited fibrosis and lipid peroxidation in rats with liver fibrosis induced by CCl4 in rats [ 67 ]. Oriental wormwood A. Chamomile Matricaria chamomilla flower extracts showed the prevention of fatty liver and hepatic inflammation in obese mice reduced damage from liver toxins and drugs like paracetamol in rats [ 697071 ].
: Quercetin and liver health| Protective and therapeutic effects of nanoliposomal quercetin on acute liver injury in rats | The TGF-β1 signaling pathway Antioxidant-rich diet mediated healht the SMAD bealth, but other effectors Hydration and joint health as phosphatidylinositol-3 Polyphenols and liver health PI3Kmitogen-activated protein Quercetin and liver health MAPKand nuclear factor kB NF-kBwhich also have key roles in cell Quercetij, apoptosis, differentiation and ECM synthesis may be involved, and can independently regulate SMAD expression 8. In CCl 4 -induced liver fibrosis, hyalinization of cytoplasm and vacuolated hepatocytes were present in addition to collagen fiber bundles. Article Contents Abstract. Quercetin significantly reduced AST, ALT, TBIL and TG content in ALD mice, compared with ALD model group Fig. Rent from DeepDyve. Visit emeraldpublishing. Alcohol metabolism can also generate a large number of toxic products, acetaldehyde, and then mediate toxicity |
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You can also search for this author in PubMed Google Scholar. and W. performed experiments. and C. designed experiments and analyzed data. supervised and coordinated experiments. supervised the overall research. All authors reviewed the manuscript. Correspondence to Xiaoming Fan or Chuanyong Guo. Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4. Reprints and permissions. Wu, L. Sci Rep 7 , Download citation. Received : 18 May Accepted : 25 July Published : 24 August Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Naunyn-Schmiedeberg's Archives of Pharmacology By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma. Skip to main content Thank you for visiting nature. nature scientific reports articles article. Download PDF. Subjects Liver fibrosis Target identification. Abstract The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Introduction Hepatic fibrosis is characteristic of liver acute or chronic injury in response to diverse metabolic, viral, and toxic stimuli. Results Neither quercetin nor surgery alone had detectable effects on normal liver tissue As shown in Fig. Figure 1. Full size image. Figure 2. Table 1 Degree of liver fibrosis in each group. Full size table. Figure 3. Figure 4. Figure 5. Figure 6. Discussion Fibrosis is a frequent consequence of liver injury and can progress to cirrhosis and even hepatocarcinoma. Figure 7. Material and Methods Reagents Quercetin was purchased from Sigma—Aldrich St. Preliminary study Twenty mice were randomly divided into four groups of five mice each. Fibrosis induction In the CCl 4 fibrosis model, mice were injected intraperitoneally with 1. Table 2 Fibrosis Score. Table 3 Nucleotide sequences of primers used for qRT-PCR. References Bataller, R. Article CAS PubMed PubMed Central Google Scholar Xi-Xian Yao, S. Article PubMed PubMed Central Google Scholar Xu, R. Article CAS Google Scholar Reeves, H. Article CAS Google Scholar Moreira, R. CAS Google Scholar Dooley, S. Article CAS PubMed Google Scholar Kim, H. Article ADS CAS PubMed PubMed Central Google Scholar Derynck, R. Article ADS CAS PubMed Google Scholar Li, J. Article CAS PubMed PubMed Central Google Scholar Cheng, P. PubMed PubMed Central Google Scholar Li, J. 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Article Google Scholar Markovs, J. Google Scholar Friedman, S. CAS PubMed Google Scholar Meurer, S. Article CAS PubMed Google Scholar Dong, C. Article PubMed PubMed Central Google Scholar Fan, X. Article ADS PubMed PubMed Central Google Scholar Tang, L. Article CAS PubMed Google Scholar Blobe, G. Article CAS PubMed Google Scholar Peng, H. Google Scholar Parsons, C. Article CAS PubMed Google Scholar Gutierrez-Ruiz, M. Article CAS PubMed Google Scholar Jia Wang, E. Article PubMed Central Google Scholar Sancho-Bru, P. Article CAS Google Scholar al, R. With the formation of lipid droplets and diffuse vacuolar degeneration, fatty degeneration and necrotic hepatocytes were widespread. Parts of hepatocytes showed typical ballooning degeneration, nuclear condensation, and shrinkage of the nuclear membrane and widespread death. Thus, the rat model of complex hepatic injury was successfully established. Effect of nanoliposomal quercetin on histopathological changes in rat liver tissues. a Normal control; b - d hepatic-injured rats with b saline treatment; c quercetin treatment; and d nanoliposomal quercetin treatment. In hepatic-injured rats with quercetin and nanoliposomal quercetin treatment, the pathologic changes of liver tissues with saline treatment were attenuated Fig. As compared with saline treatment in hepatic-injured rats, nanoliposomal quercetin treatment showed intact structures of the hepatic lobule and liver cells, accompanied by resolved fatty change, no obvious fibrosis formation and no obvious infiltrates of interstitial inflammatory cells Fig. Our data indicate that treatment with nanoliposomal quercetin could reduce hepatic injury and protect hepatocytes against damage effectively. Many kinds of factors including biological damage such as with hepatitis virus [ 17 ], chemical damage such as with drugs [ 18 , 19 ], and physical damage such as with liver transplantationcan [ 20 , 21 ] lead to liver injury. The use of carbon tetrachloride [ 22 ] and other composite factors such as a high-fat, high-cholesterol, and low-protein diet as well as alcohol drinking can induce liver injury models in animals, with pathological results very similar to human chronic liver diseases. Quercetin is a hepatoprotective drug [ 23 ] but with poor solubility and bioavailability in liver [ 14 , 24 ]. In this study, we used liposomal nanoparticles as the drug carrier loading quercetin to improve the solubility and bioavailability of quercetin in liver and protect rats against acute liver injury. Moreover, it possesses anticancer effects [ 27 , 28 ], prevents the development of hepatic fibrosis [ 29 , 30 ], and reduces toxicant-induced liver injury [ 8 , 11 ]. However, the limited solubility of quercetin in water and poor bioavailability in liver present a major problem for its administration as a chemopreventer. Our study used a drug carrier, liposome, to entrap quercetin. The main component of liposomes is phospholipids, which has a typical feature of both hydrophilicity and hydrophobicity. It can be used as a drug carrier to bind with a variety of drugs and has many advantages, such as good biocompatibility, no toxic effects and good bioavailability [ 9 , 13 ]. Furthermore, we nanoformulated the liposome-entrapped quercetin compound to improve the utilization of quercetin and targeting to the liver [ 13 ] quercetin in the liver to improve its bioavailability [ 31 ]. Quercetin was located in the middle of lipid bilayer with the drug loading about 5. The nanoparticles are stable in the form of freeze-dried powder for a long time storage and resuspend in 0. All the components of nanoparticles can be easily biodegradable and amenable to physiological excretion. Under physiological conditions, the content of transaminase in liver cells is about times that in peripheral blood. The hepatic cellular membranes can be damaged by various pathogenic factors, with some enzymes secreting to peripheral blood. Thus, transaminases GPT and GOT in serum are sensitive indicators of hepatocyte damage and can reflect the severity of liver injury to a certain extent [ 32 ]. The liver is the main organ of bilirubin metabolism, and liver cells are the only cells that can form direct bilirubin DBIL. Therefore, the level of serum bilirubin, especially DBIL, can comprehensively reflect the functional status of liver cells including their intake, transport, binding and excretion. We use carbon tetrachloride and other composite factors such as a high-fat, high-cholesterol, and low-protein diet as well as alcohol drinking, which can induce liver injury in animalswith pathological results very similar to human chronic liver diseases. As compared with the control group, hepatic-injured rats showed significantly decreased food intake, body weight and activity accompanied by poor light reactions. With the treatment of pure quercetin and nanoliposomal quercetinin in rats with hepatic injury, the body weight of hepatic-injured rats was increased significantly while the liver index and the values of GPT, GOT and DBIL markedly decreased as compared with saline treatment Fig. Moreover, Histopathological analysis Fig. Interestingly, nanoliposomal quercetin was more effective on decreasing liver index and interstitial inflammatory infiltration of hepatic-injured rats than pure quercetin, which indicated that the protective effect of nanoliposomal quercetin in the injured liver was stronger than that of pure quercetin. Further studies should define the therapeutic efficacy of the nanoliposome-entrapped quercetin compound and detect onset time, organ distribution and the pharmacokinetics of quercetin in vivo in order to provide a more efficacy profile for this promising therapeutic agent. Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Article Google Scholar. 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XL and YZ performed animals experiments, data acquisition, the decision to publish and manuscript preparation. LL revised the manuscript and provided valuable advices. YP and YH contributed to the image modification. PY helped finish some experimental works. ML supervised the studies, designed the experiments and interpreted the results. All authors had made joint efforts to ensure that the final version of this study is more reliable and integrated. All authors read and approved the final manuscript. Correspondence to Mingmei Liao. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is distributed under the terms of the Creative Commons Attribution 4. Reprints and permissions. Liu, X. et al. Protective and therapeutic effects of nanoliposomal quercetin on acute liver injury in rats. BMC Pharmacol Toxicol 21 , 11 Download citation. |
| Please note you do not have access to teaching notes | Licer of hepatology 33— Hydration and joint health 22— About QJM Editorial Board Author Herbal weight loss techniques Facebook Twitter Purchase Recommend to your Library Advertising livrr Corporate Services Journals Career Network. Daglioglu C. Quercetin has anti-inflammatory and antitumor activity, is an antioxidant, and has been reported to decrease the risk of chronic health conditions including cardiovascular and neurodegenerative diseases, diabetes, and tumorigenesis 1415 And the qRT-PCR results for LN and HA were accordance with serum results. |
| Quercetin Information | Mount Sinai - New York | The aim of the current study was to assess the effect of quercetin on hematological parameters in NAFLD patients. Int J Stem Cells. Kurowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piche LA, Serratore P. A choleretic effect was seen in rats and guinea pigs with paracetamol-induced liver damage [ 44 ]. Dietary Sources Fruits and vegetables are the primary dietary sources of quercetin, particularly citrus fruits, apples, onions, parsley, sage, tea, and red wine. Related Articles. Article ADS CAS PubMed PubMed Central Google Scholar Verma, R. |
| Clinical Nutrition Research | Boswellia serrata extract had liver-protective effects in Hydration and joint health with kiver damage [ 22 ]. and W. And Beclin-1 combines Hydration and joint health halth diaphragm and generate the production Multivitamin weight loss supplements an Atgs ajd. Acknowledgements This work was supported by the National Natural Science Foundation of China grant numbers and Previous studies that evaluated the effects of quercetin on hepatic fibrosis did not include signaling pathways or autophagy 26272829 Received : 27 July The effect of quercetin on AST, ALT, TBIL and TG levels. |
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