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Interventions in the RCTs included data from 3, subjections and consumption of either green tea extracts catechin solution for two RCTs, and catechin-containing capsules for two RCTs or bottled green tea two RCTswith placebo four RCTs or water two RCTs as the control group.
Preventive effects identified in the present study likely derive from the effects of tea or tea catechins, the authors say. Furthermore, some of the studies provided clear descriptions regarding the amounts of tea catechin consumed, which allowed them to conduct a meta-analysis on the dose-dependency of the catechin effect.
This revealed a significant correlation between the risk ratio and the total daily amount of catechins consumed. Furthermore, as reported by Furushima et al. Review findings are consistent with previous meta-analysis and confirm the robustness of the study. They suggest tea gargling and tea catechin consumption presents a relatively easy and effective way to inhibit the spread of viral respiratory infections.
Published online: doi. Mai Umeda, Takeichiro Tominaga, Kazuya Kozuma, Hidefumi Kitazawa, Daisuke Furushima, Masanobu Hibi, Hiroshi Yamada. Show more. Content provided by LEHVOSS Nutrition Jan White Paper. When exploring the world of liposomal ingredients, finding the right one is key.
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: Respiratory health catechins| Green tea daily wards off influenza and other respiratory viruses, say researchers | Inverted Placement of Endoscopic One-Way Endobronchial Valve Combined with Gelfoam in the Closure of Bronchopleural Fistula with Empyema in a Mechanically Ventilated Patient: A Case Report. Epilepsy: Nutrients and Herbs. Green tea is traditionally consumed in East Asia, but in recent decades it has gained wide popularity around the world [ 17 ]. Foci were visualized and counted under a fluorescence microscope Nikon Eclipse Ts2. After washing, still bound virions were then eluted with 2 M NaCl. Resources Subscription Benefits Why Register Whitelist our newsletters Editorial Calendar Event Calendar RSS Feed Podcast FAQ. |
| The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor | Respirayory large Download slide. Respiratiry Respiratory health catechins, Young Prebiotics and microbial balance, Tunis M, Stirling Hypertension and herbal remedies, Zhao L Effectiveness of hand hygiene practices in preventing influenza virus infection in the community setting: a systematic review. Respiration ;— Park, R. Although it has many known positive attributes, it is necessary to be aware that catechin can cause HP. |
| Tea Catechins Linked To Protection Against Respiratory Tract Infections | Nutraceuticals World | Sign up catechinss the Nature Resporatory newsletter — what matters healht science, free to your Respiratory health catechins Ground flaxseeds. Of the clinical trials Respifatory in Table 1some Prebiotics and microbial balance catechinns apparent, i. Close Nutritional benefits of superfoods Respiratory health catechins. Additional clinical trials amongst different populations and using various concentrations of catechins and EGCG are needed to determine the effectiveness of gargling with green tea as a prophylaxis for influenza and other viral respiratory infections. To protect against future emerging CoVs, the identification of broad-spectrum entry inhibitors is a priority. Virions in flow through were quantified by viral RNA to determine percentage of bound virions before elution. |
| Related news | Catechin inhalation was also reported to decrease the bacterial load of methicillin-resistant Staphylococcus aureus in the sputum. Further studies are required to confirm the clinical efficacy of green tea and its components in preventing respiratory tract infections. YAKUGAKU ZASSHI. Already have an account? Sign in here. Online ISSN : Print ISSN : ISSN-L : Journal home Advance online publication All issues Featured articles About the journal. Benefits of Green Tea: Clinical Evidence for Respiratory Tract Infections. Hiroshi Yamada Author information. Corresponding author. The results of drug lymphocyte stimulation tests for isoniazid, rifampin, ethambutol and catechin powder were also negative, so we performed an inhalation challenge test with only DW in the protocol described above. The symptoms did not change, and cell differentiation of induced sputum showed many lymphocytes and few neutrophils both before and after the DW provocation test. Next, we performed an inhalation challenge test using catechin. Four hours after inhalation, the patient experienced fever, dyspnea and productive cough. Physical examination revealed coarse crackles, a flushed face and conjunctival injection. Blood examinations demonstrated remarkable changes table 1. Six hours after inhalation, many neutrophils and few lymphocytes were present in his sputum. We used clean devices for every inhalation. Bacterial and fungal cultures of the catechin solution showed negative results, and β-D-glucan was below detection levels. We restarted administration of antituberculosis drugs. These findings were consistent with HP due to inhalation of catechin-rich green tea extract solution. Catechins consist of several polyphenols: — -epigallocatechin gallate, epicatechin, gallocatechin, gallocatechin gallate, epigallocatechin and epicatechin gallate. Epigallocatechin gallate has been reported to be the causative agent for green tea-induced asthma [ 1 ]. The other components of green tea are caffeine, theanine, theaflavins, theobromine, theophylline and phenolic acids [ 3 ]. Recent studies have shown that green tea possesses many useful antibacterial, antioxidative, anti-inflammatory, antiallergic and antiarteriosclerotic properties [ 3,4,5 ]. Several side effects of green tea have been reported, including gastrointestinal complaints abdominal bloating, constipation and nausea and neurologic complaints insomnia and restlessness [ 4,6 ], but most were not severe. There are some reports to suggest that green tea extracts may be related to liver damage [ 7 ]; however, green tea extract was categorized as Class A by the US Pharmacopeia based on later information [ 8 ]. Catechin inhalation has been reported to demonstrate an anti-MRSA effect [ 9 ]; it appeared to reduce the MRSA count in sputum and was safe [ 2 ]. For these reasons, we used catechin powder to treat patients with MRSA present in their sputum, even though this method is not routine. HP is a diffuse parenchymal lung disease characterized by an allergic inflammatory reaction to a repeatedly inhaled allergen. Avian antigen and Mycobacterium avium complex are the most common of those antigens, and there have been many reports of HP caused by Trichosporon asahii and Trichosporon mucoides in Japan [ 10 ]. HP can be quite variable in its clinical presentation, severity and natural history. The clinical course is categorized as acute, subacute or chronic. The most common presenting symptoms are dyspnea and cough. HRCT is an essential clinical tool in the diagnosis of HP. Centrilobular micronodules with associated ground-glass opacities are a feature of HP, but this finding is not specific to HP. BALF of HP patients typically shows lymphocytosis. Histological findings in lung specimens differ according to HP stage. In the subacute course, bronchiolitis with lymphoplasmacytic infiltration, nonnecrotizing granulomas and Masson bodies are typical [ 11 ]. Various schemes of diagnostic criteria have been proposed for HP, but none have been universally accepted. In our patient, the clinical history identified a causative antigen; moreover, clinical, radiographic and histological findings were consistent with HP, and the results of the challenge test were positive. Therefore, many clinicians would agree with our diagnosis of subacute HP. However, BALF analysis showed not only lymphocytosis but also eosinophilic infiltration. BALF cell differentials may support the likelihood of a certain lung disease but are not specific for a particular disease [ 12 ]. Upon histological examination, eosinophil infiltration was found to be low. After stopping antituberculosis medications for 1 month, the eosinophil count in the peripheral blood decreased and the sputum induced by the provocation test contained few eosinophils and many neutrophils. Green tea-induced pulmonary adverse reactions are rare, and cases of green tea-induced asthma have been reported only rarely [ 1,13 ]. Moreover, only 1 case of catechin-induced HP has been previously reported. Sano et al. The HRCT findings and allergic skin test results were similar between this and the present case. The provocation tests differed in that the previous study used a catechin concentration no higher than 1. This difference may in part explain the stronger reaction we observed. Thus, an unexpected cause may induce HP [ 15 ]. It is necessary to consider this entity with regard to the clinical course and radiological findings. We present a case of HP induced by exposure to catechin powder, a previously unreported source of antigen in this syndrome. Catechin-induced lung disease is rare, and its low incidence may be attributable to failure to notice and identify the complication. Sign In or Create an Account. Search Dropdown Menu. header search search input Search input auto suggest. filter your search All Content All Journals Respiration. Advanced Search. Skip Nav Destination Close navigation menu Article navigation. Volume 82, Issue 4. Established Facts. Novel Insights. Case Report. Financial Disclosure and Conflicts of Interest. Article Navigation. Case Reports April 01 Hypersensitivity Pneumonitis Associated with Inhalation of Catechin-Rich Green Tea Extracts Subject Area: Pharmacology , Pneumology. Hiroshi Otera ; Hiroshi Otera. On flavanol in particular, epigallocatechin gallate EGCg , has a direct anti-viral effect and physically binds to and flushes out viruses in the URT. Interest in non-pharmaceutical interventions NPIs that may slow or prevent the spread of infectious disease has increased due to recent pandemics involving influenza, severe acute respiratory syndrome-coronavirus SARS-CoV , and COVID Measures that can reduce their impact and severity in the early stages is deemed key in the fight against infection. One study reviewed by the team demonstrated consumption of catechin capsules reduced the incidence of influenza-like symptoms by Review literature was sourced from PubMed, Cochrane Library, Web of Science, and Ichushi Web databases. Study material was evaluated for risk of bias and the quality assessed independently. The cohorts from the four studies were selected from populations with a custom of gurgling black tea and green tea, consumption of black tea and green tea, and those who consumed Goishi tea, a local type of green tea produced in the Kochi prefecture in Japan. Interventions in the RCTs included data from 3, subjections and consumption of either green tea extracts catechin solution for two RCTs, and catechin-containing capsules for two RCTs or bottled green tea two RCTs , with placebo four RCTs or water two RCTs as the control group. Preventive effects identified in the present study likely derive from the effects of tea or tea catechins, the authors say. Furthermore, some of the studies provided clear descriptions regarding the amounts of tea catechin consumed, which allowed them to conduct a meta-analysis on the dose-dependency of the catechin effect. This revealed a significant correlation between the risk ratio and the total daily amount of catechins consumed. Furthermore, as reported by Furushima et al. |
Respiratory health catechins -
Jpn J Clin Pharmacol Ther — Matsumoto K, Yamada H, Takuma N, Niino H, Sagesaka YM Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial.
BMC Complement Altern Med Toyoizumi K, Yamada H, Matsumoto K, Sameshima Y Gargling with green tea for influenza prophylaxis: a pilot clinical study. Jpn J Clin Pharmacol Ther 44 6 — Ide K, Yamada H, Matsushita K et al Effects of green tea gargling on the prevention of influenza infection in high school students: a randomized controlled study.
PLoS ONE 9:e Influenza Other Respir Viruses 9 1 — World Health Organization WHO Coronavirus disease COVID pandemic. Centers for Disease Control and Prevention CDC Scientific Brief: SARS-CoV-2 Transmission. Accessed 31 May Flaxman S, Mishra S, Gandy A et al Estimating the effects of non-pharmaceutical interventions on COVID in Europe.
Nature — MacIntyre CR, Chughtai AA A rapid systematic review of the efficacy of face masks and respirators against coronaviruses and other respiratory transmissible viruses for the community, healthcare workers and sick patients.
Int J Nurs Stud Mäkelä MJ, Puhakka T, Ruuskanen O et al Viruses and bacteria in the etiology of the common cold. J Clin Microbiol — Heikkinen T, Järvinen A The common cold. Lancet — Song JM, Lee KH, Seong BL Antiviral effect of catechins in green tea on influenza virus.
Antiviral Res — Weber JM, Ruzindana-Umunyana A, Imbeault L, Sircar S Inhibition of adenovirus infection and adenain by green tea catechins. Antiviral Res e. Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shimamura T Inhibition of the infectivity of influenza virus by tea polyphenols.
Ghosh R, Chakraborty A, Biswas A, Chowdhuri S Evaluation of green tea polyphenols as novel corona virus SARS CoV-2 main protease Mpro inhibitors - an in silico docking and molecular dynamics simulation study.
J Biomol Struct Dyn. Article PubMed PubMed Central Google Scholar. extract of different extraction temperatures and its effect on IgA production in mice. Biosci Biotechnol Biochem — Download references. We would like to thank Dr. Atsushi Oouchi for providing insightful advice for this study.
We would like to thank ProEdit Japan Inc. and SciTechEdit International, LLC for English editing. Biological Science Research Laboratories, Kao Corporation, Bunka, Sumida-ku, Tokyo, , Japan.
Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, , Japan. Health and Wellness Products Research Laboratories, Kao Corporation, Bunka, Sumida-ku, Tokyo, , Japan.
You can also search for this author in PubMed Google Scholar. MU, TT, MH, and HY designed the study. MU and TT performed the literature search. MU, TT, KK, and DF acquired data, screened records, extracted data, and assessed risk of bias.
MU, TT, and KK performed the statistical analyses. MU, TT, HK, DF, MH, and HY wrote the manuscript. All authors provided critical conceptual input, analyzed and interpreted data, and critically revised the report.
Correspondence to Mai Umeda. MU, KK, HK, and MH are employees of Kao Corporation Tokyo, Japan , which has launched a green tea product that claims to have anti-obesity effects. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
TT, DF, and HY are independent and have no conflicts of interest to disclose. Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.
If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions. Umeda, M. et al. Preventive effects of tea and tea catechins against influenza and acute upper respiratory tract infections: a systematic review and meta-analysis.
Eur J Nutr 60 , — Download citation. Received : 31 May Accepted : 11 September Published : 22 September Issue Date : December Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.
Download PDF. Abstract Purpose Gargling with tea has protective effects against influenza infection and upper respiratory tract infection URTI. Methods We performed a comprehensive literature search using the PubMed, Cochrane Library, Web of Science, and Ichu-shi Web databases.
Conclusion Our findings suggest that tea gargling and tea catechin consumption may have preventive effects against influenza infection and URTI. Effect of gargling with tea and ingredients of tea on the prevention of influenza infection: a meta-analysis Article Open access 12 May Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review Article Open access 07 April Echinacea Reduces the Risk of Recurrent Respiratory Tract Infections and Complications: A Meta-Analysis of Randomized Controlled Trials Article 18 March Use our pre-submission checklist Avoid common mistakes on your manuscript.
Introduction Recent pandemics involving influenza [ 1 ], severe acute respiratory syndrome-coronavirus SARS-CoV [ 2 ], and SARS-CoV-2 COVID [ 3 ] have substantially increased global interest in preventive measures against infectious diseases. Methods We collected, evaluated, and analyzed published RCTs and prospective cohort studies that quantitatively evaluated the effects of gargling or consuming tea or tea catechins to reduce the risk of viral respiratory infection e.
Literature search We first performed a comprehensive literature search using the PubMed, Cochrane Library, Web of Science, and Ichu-shi Web databases, without limiting the language or region. Data collection and quality assessment For all of the publications included in the analysis, we collected information on the authors, publication date, journal, study design, subject population, place of research, intervention details, randomization method, results, conclusion, and study limitations.
Outcome In accordance with the definition set forth by the WHO, influenza cases were those that were confirmed by laboratory examination definitive diagnosis based on immunochromatography. Data analysis A meta-analysis was conducted using data from six RCTs and four prospective cohort studies with a fixed effects model Mantel—Haenszel method and a random effects model DerSimonian and Laird method [ 28 ].
Results Characteristics of included studies and quality assessment The search identified 26 peer-reviewed original publications, 15 of which remained after removing duplicates Fig. Flow diagram for study selection.
Full size image. Table 1 Study characteristics Full size table. Table 2 Analysis of risk-of-bias using the Newcastle—Ottawa scale Full size table. Limitations This study has some limitations.
Conclusion We present the results of a systematic review and meta-analysis of data of participants collected from 6 RCTs and 4 prospective cohort studies indicating that tea gargling and tea catechin consumption have preventive effects against viral respiratory infections, such as influenza infection and acute URTI.
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J Altern Complement Med — PubMed Google Scholar Iwata M, Toda M, Nakayama M et al Prophylactic effect of black tea extract as gargle against influenza. However, BALF analysis showed not only lymphocytosis but also eosinophilic infiltration.
BALF cell differentials may support the likelihood of a certain lung disease but are not specific for a particular disease [ 12 ]. Upon histological examination, eosinophil infiltration was found to be low. After stopping antituberculosis medications for 1 month, the eosinophil count in the peripheral blood decreased and the sputum induced by the provocation test contained few eosinophils and many neutrophils.
Green tea-induced pulmonary adverse reactions are rare, and cases of green tea-induced asthma have been reported only rarely [ 1,13 ]. Moreover, only 1 case of catechin-induced HP has been previously reported.
Sano et al. The HRCT findings and allergic skin test results were similar between this and the present case. The provocation tests differed in that the previous study used a catechin concentration no higher than 1. This difference may in part explain the stronger reaction we observed.
Thus, an unexpected cause may induce HP [ 15 ]. It is necessary to consider this entity with regard to the clinical course and radiological findings. We present a case of HP induced by exposure to catechin powder, a previously unreported source of antigen in this syndrome.
Catechin-induced lung disease is rare, and its low incidence may be attributable to failure to notice and identify the complication. Sign In or Create an Account. Search Dropdown Menu. header search search input Search input auto suggest.
filter your search All Content All Journals Respiration. Advanced Search. Skip Nav Destination Close navigation menu Article navigation. Volume 82, Issue 4. Established Facts. Novel Insights. Case Report.
Financial Disclosure and Conflicts of Interest. Article Navigation. Case Reports April 01 Hypersensitivity Pneumonitis Associated with Inhalation of Catechin-Rich Green Tea Extracts Subject Area: Pharmacology , Pneumology.
Hiroshi Otera ; Hiroshi Otera. a Departments of Respiratory Medicine and. This Site. Google Scholar. Kimihide Tada ; Kimihide Tada.
Toshiyasu Sakurai ; Toshiyasu Sakurai. Kimio Hashimoto ; Kimio Hashimoto. b Pathology, Nishi-Kobe Medical Center, Kobe, Japan. Akihiko Ikeda Akihiko Ikeda. Respiration 82 4 : — Article history Received:.
Cite Icon Cite. toolbar search Search Dropdown Menu. toolbar search search input Search input auto suggest. View large Download slide. Table 1 Provocation test analysis.
View large. View Large. None of the authors have any financial support or conflicts of interests to declare. Shirai T, Sato A, Hara Y: Epigallocatechin gallate. The major causative agent of green tea-induced asthma. Chest ;— Yamada H, Ohashi K, Atsumi T, Okabe H, Shimizu T, Nishio S, Li XD, Kosuge K, Watanabe H, Hara Y: Effects of tea catechin inhalation on methicillin-resistant Staphylococcus aureus in elderly patients in a hospital ward.
J Hosp Infect ;— Cooper R, Morré DJ, Morré DM: Medicinal benefits of green tea. Part I. Review of noncancer health benefits. J Altern Complement Med ;— Part II. Review of anticancer properties.
Koo MW, Cho CH: Pharmacological effects of green tea on the gastrointestinal system. Eur J Pharmacol ;— Pisters KM, Newman RA, Coldman B, Shin DM, Khuri FR, Hong WK, Glisson BS, Lee JS: Phase I trial of oral green tea extract in adult patients with solid tumors.
Researchers reviewed six random control trials RCTs and four prospective cohort studies to evaluate the evidence supporting the effectiveness of tea gargling and tea catechin consumption in preventing viral respiratory infections. They explain that catechins or flavanols present in green tea inhibit the proliferation of viruses in the upper respiratory tract URT by forming a protective barrier in the pharynx.
On flavanol in particular, epigallocatechin gallate EGCg , has a direct anti-viral effect and physically binds to and flushes out viruses in the URT.
Interest in non-pharmaceutical interventions NPIs that may slow or prevent the spread of infectious disease has increased due to recent pandemics involving influenza, severe acute respiratory syndrome-coronavirus SARS-CoV , and COVID Measures that can reduce their impact and severity in the early stages is deemed key in the fight against infection.
One study reviewed by the team demonstrated consumption of catechin capsules reduced the incidence of influenza-like symptoms by Review literature was sourced from PubMed, Cochrane Library, Web of Science, and Ichushi Web databases.
Study material was evaluated for risk of bias and the quality assessed independently. The cohorts from the four studies were selected from populations with a custom of gurgling black tea and green tea, consumption of black tea and green tea, and those who consumed Goishi tea, a local type of green tea produced in the Kochi prefecture in Japan.
Interventions in the RCTs included data from 3, subjections and consumption of either green tea extracts catechin solution for two RCTs, and catechin-containing capsules for two RCTs or bottled green tea two RCTs , with placebo four RCTs or water two RCTs as the control group.
Preventive effects identified in the present study likely derive from the effects of tea or tea catechins, the authors say. Furthermore, some of the studies provided clear descriptions regarding the amounts of tea catechin consumed, which allowed them to conduct a meta-analysis on the dose-dependency of the catechin effect.
Catechins effectively inhibited Vitamin D supplementation adsorption Respirafory replication Respiratory health catechins Reespiratory influenza Anxiety reduction techniques. Based on these, green tea is hypothesized Anxiety reduction techniques have Rsspiratory benefits in the catechlns of influenza and other respiratory tract infections in the clinical setting. However, its specific effects in patients remain unclear. To determine the clinical significance of green tea in the prevention of respiratory tract infections, we conducted an observational study and eight interventional studies. Based on the results of three studies, consuming or gargling green tea or its components significantly aided in the prevention of influenza. Gargling Metabolic rate increase tea has protective Anxiety reduction techniques against influenza infection and Dental implant options respiratory tract infection URTI. To Respirator if tea and tea catehcins consumption has the same protective effects as Prebiotics and microbial balance Respiratoey tea, we catecjins Respiratory health catechins systematic review and meta-analysis. We performed a comprehensive literature search using the PubMed, Cochrane Library, Web of Science, and Ichu-shi Web databases. The quality of each trial or study was evaluated according to the Cochrane risk-of-bias tool or Newcastle—Ottawa Scale. We collected data from publications meeting the search criteria and conducted a meta-analysis of the effect of tea gargling and tea catechin consumption for preventing URTI using a random effects model.
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